A Systems-Level Terminology for Microbiome-Mediated Inflammatory Regulation: Panflemmosis, Dysgutome, Colobiota, EuColobiota, Micrometabionics, and Colo-Mycobiota Overgrowth (COMO)

We can now measure the microbiome in extraordinary detail, but we still describe it with a language built for simpler biology. In inflammation research, this mismatch has become a real conceptual bottleneck. Here, I introduce a systems-level terminology to address this gap.

REYED M R Feb 07, 2026

I’m pleased to share the release of a systems-level terminological framework focused on microbiome-mediated inflammatory regulation. This work introduces and consolidates a set of interrelated concepts—Panflemmosis, Dysgutome, Colobiota, EuColobiota, Micrometabionics, and Colo-Mycobiota Overgrowth (COMO)—within a unified conceptual architecture.

The goal is to provide a coherent vocabulary that connects host–microbiome interactions, inflammatory regulation, and metabolic signaling at a systems level, and to support future applications in multi-omics integration, AI-assisted analysis, and translational systems medicine.

This framework is intended as a foundational reference for researchers working across microbiome science, immunometabolism, and systems medicine, helping to standardize terminology and improve conceptual alignment across disciplines.

The full foundational report is available on Zenodo with a DOI, establishing the formal definitions and scope of these terms.

I welcome feedback, discussion, and potential collaborations with colleagues interested in systems-level modeling of host–microbiome–inflammation networks.

📄 Read & Cite: DOI: 10.5281/zenodo.18511678

License: CC BY 4.0 – Credit required for redistribution and reuse.