The meta-analysis indicated a link between certain PTPN22 gene variations, specifically the rs2476601 polymorphism, and an elevated risk of autoimmune disorders such as rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus. The aggregated data showed that those with the risk allele were more likely to acquire autoimmune diseases, particularly in European populations. These results emphasize PTPN22's importance as a key genetic driver in autoimmune pathogenesis, as well as its potential as a biomarker for early detection and targeted treatment.
Deciphering autoimmune susceptibility: a meta-analysis of PTPN22 gene variants
Autoimmune illnesses result from an abnormal immune reaction against the body's tissues. Genetic factors play an important role in determining susceptibility to certain diseases.