Autism is a disorder caused by the environment when it was first identified. It has been revealed to be a highly complex and complicated genetic disorder due to decades of study. Epigenetics, sex-linked modifiers, CNVs, double-hit mutations, and environmental influences are examples of such modifiers. Many decades of study may be required before the scientific community has a solid understanding of how these modulators contribute to the development of ASD. A simplified genetic testing methodology, such as a microarray with known risk loci, might be a quick and low-cost way to determine what is causing the problem. More research is needed, but it will ultimately lead to a better understanding of how causal genetic components and disease modifiers interact to create ASD. Biomarkers have the potential to help identify people who are at risk of developing ASD before diagnostic behaviors emerge. Maternal–fetal brain autoantibodies seem to be the most promising prenatal biomarker, with high specificity for offspring developing ASD.
Investigation of Genetic Polymorphism in Autism Spectrum Disorder: a Pathogenesis of the Neurodevelopmental Disorder
Autism spectrum disorders (ASDs) are a set of neurodevelopmental illnesses characterized by three primary behavioral impairments. Limited interests, repetitive activity, and inability to participate in reciprocal social relationships are characteristics of behavioral disorders.