What began as an educational talk at a European cancer research conference has evolved into a comprehensive guide for early-career scientists navigating the complex landscape of breast cancer research. A Guide to Breast Cancer Research: From Cells and Molecular Mechanisms to Therapy is a curated textbook on the most pressing topics in breast tissue development and breast cancer, authored by leading experts in the field.
Edited by Therese Sørlie and Robert B. Clarke, whose scientific careers have been centered on breast cancer research, the book offers a structured overview of key concepts, from embryonic mammary gland development to the intricacies of tumorigenesis, metastasis and therapy resistance. It lays the groundwork for understanding model systems, cellular heterogeneity, and the cells of origin in both normal breast development and cancer. Readers are guided through the molecular basis of breast cancer, including some of the most relevant signaling pathways, mechanisms of immune response and dormancy, and the challenges of treatment resistance.
Each chapter is designed with clarity in mind: key points, summary boxes, and concise conclusions make the content accessible. The book aims to help young investigators grasp the methodologies and advances that are shaping the future of breast cancer research.
Are you studying breast development, cancer heterogeneity, or therapy resistance? Then this book should be on your desk. It is a resource designed to inspire and inform the next generation of researchers, those ready to ask new questions and push the boundaries of what’s known.