Polybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology

As microbiome research moves toward multi-omics and AI-driven analysis, the gap between data richness and conceptual integration is becoming harder to ignore. This post introduces the first volume of a systems-level framework designed to address that gap.

REYED M R Feb 08, 2026

I’m sharing the release of Polybiome Systems Medicine (PSM), Volume I, which focuses on the vision and foundational methodology of a systems-level approach to host–microbiome–inflammation interactions.

The aim is to move beyond fragmented views of the microbiome and toward a coherent architecture that integrates conceptual structure, methodological foundations, and translational thinking. This volume lays out the core framework, defines the guiding principles, and establishes the conceptual and terminological basis needed for consistent systems-level reasoning in this space.

PSM is designed to support:

Integration of microbiome, immunometabolism, and inflammation at a systems level
Methodological alignment with multi-omics and AI-assisted analysis
Translational use cases in complex, chronic, and metabolic diseases

Rather than adding complexity, the goal is to provide a clearer structure for thinking, modeling, and communicating about biologically complex, network-driven phenomena.

The foundational report is available on Zenodo with a DOI and is intended as a reference point for future methodological and applied work within the PSM framework.

I welcome discussion, critique, and collaboration from colleagues working in systems medicine, microbiome research, and translational biology.

REYED, R. M. (2026). Polybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology (0.1). Zenodo. https://doi.org/10.5281/zenodo.18294835