T2DM poses a major global health challenge, with its prevalence rising quickly, especially in countries such as India. Genetic factors, including those associated with the HHEX gene, are crucial in T2DM susceptibility. The rs1111875 polymorphism within HHEX has emerged as a key genetic variant linked to T2DM, mainly through GWAS across diverse populations. Although previous research on the genetic association between HHEX and T2DM has yielded mixed results, our meta-analysis specifies a more precise interpretation of this relationship. By emphasizing the significance of genetic markers like HHEX, this study underscores the potential for personalized medicine in predicting T2DM risk and tailoring treatment approaches based on individual genetic profiles. This more profound understanding of genetic contributions to T2DM could lead to more effective strategies for managing and preventing this chronic condition.
The association of rs1111875 in HHEX with type 2 diabetes: A comprehensive meta-analysis
T2DM is the prevailing form of diabetes, representing over 90% of all instances. It mainly arises from insulin resistance and irregular insulin production. As T2DM continues to rise, particularly in India, gaining insight into the genetic factors influencing the disease is essential.