Cell Death & Disease
This journal seeks to encompass the breadth of translational implications of cell death and promote diverse and integrated areas of experimental and internal medicine with its specialties, including cancer, immunity and neuroscience.
Melatonin may help fight bladder cancer (BLCA) by slowing cancer cell energy production and increasing chemotherapy effectiveness, by targeting ENO1 to enhance gemcitabine’s impact and involving reactive oxygen species and PPARγ regulation. This suggests new methods for improving BLCA treatment.
USP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer
This study identified USP43 as a deubiquitinase which regulates glycolytic metabolism and c-Myc transcriptional activity and revealed a USP43/c-Myc positive feedback loop that contributes to the progression of BLCA.