Cell Discovery
This journal aims to provide an open access platform for scientists to publish their outstanding original works and publishes results of high significance and broad interest in all areas of molecular and cell biology.
Homotrimeric architecture of viral G protein-coupled receptor UL78
UL78, a human cytomegalovirus encoded GPCR, interrupts normal signaling or presents oligomers to modulate functions of other viral GPCRs and host GPCRs. In this study, we report the cryo-EM structure of UL78 and unveil a novel form of GPCR oligomerization unseen before − a homotrimeric architecture.
Safety and Feasibility of Anti-CD19 CAR T Cells Expressing Inducible IL-7 and CCL19 in Patients with Relapsed or Refractory Large B-cell Lymphoma
In this study, Lei et al. first report the preclinical and the phase 1 clinical trial results of CD19-specific CAR-T cells capable of expressing interleukin (IL)-7 and chemokine (C-C motif) ligand (CCL)-19 ( 7 × 19 CAR-T cells) in patients with R/R LBCL.
