Communications Biology
An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
Telomere maintenance and tumor cell differentiation have been separately investigated in neuroblastoma malignancy. Their mechanistic connection is unclear. We establish a tight and reciprocal causal relationship between the telomere and differentiation programs of high-risk neuroblastoma.
Cornering the interactome to kill cancer cells
Joshi et al reveal how manipulating cancer cell protein-protein interactions networks (i.e. interactomes) eliminates rebound pathways, turning traditionally less effective therapeutics highly efficacious.
