Communications Biology
An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Chemiluminescent screening of specific hybridoma cells via a proximity-rolling circle activated enzymatic switch
A 1-day homogeneous chemiluminescent screening protocol for specific hybridoma cells via a proximity-rolling circle activated enzymatic switch (P-RCAES) strategy has been developed. This CL assay enables the screening of specific hybridoma cells on conventional 96-well plate at single-cell level.