Communications Biology
An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Age-Dependent, Motor Cortex Selective TARDBP Demethylation Unlock the Mystery in Amyotrophic Lateral Sclerosis
Our paper indicates DNA demethylation of the autoregulatory region of TDP-43 interferes with the TDP-43 autoregulation resulting in increasing TDP-43. The DNA demethylation increases in the human motor cortex by age. The tissue-specific, age-dependent demethylation may underlie the nature of ALS.
A window into the past
Environmental changes and historical population dynamics of lemurs in Madagascar over the past 25,000 years.
Insight into RNA binding proteins regulation opens new frontiers in amyotrophic lateral sclerosis
RNA binding proteins play multiple roles in RNA metabolism, and their mutation, delocalization and/or altered expression have been proposed to cause amyotrophic lateral sclerosis. Elucidating the underlying molecular mechanisms is of crucial importance to design therapeutic approaches.
A chromosome-wide view of an exceptionally diverse helminth
By resolving the chromosomes of the gastrointestinal parasitic nematode, Haemonchus contortus, we have provided unique insights into the chromosomal evolution and genome-wide diversity of this globally important pathogen.
