Communications Biology
An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
B Cells: At the intersection of enhanced responses to immunotherapy treatments
B cells have strong clinical significance as drivers of antitumor immunity in triple negative breast cancer. While B cells are known to enhance T cell-mediated tumor killing, we have also uncovered a potential regulatory function, in which they suppress myeloid-derived suppressor cells.
Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci
This study identified 43 novel non-HLA loci associated with Type 1 diabetes (T1D) in patients harboring low GRS.
The truth behind the story of neutrophil-derived ROS in promoting tumor colonization
Tumor colonization is counteracted by IL-1β-secreting tissue neutrophils.
An in situ activity assay for lysyl oxidases
Current methods for detecting activity of lysyl oxidases lack specificity and do not provide information on how much activity is occurring in situ. Hydrazide reagents can be used to measure their in situ activity levels in a practicable, sensitive, and specific manner.
Plant-like SPX-PHR-PSI regulatory cascade operates in phytoplankton
Phytoplankton are aquatic counterparts of plants, contributing 50% of CO2 drawdown and O2 production. They also are the base of the marine food chain. Like plants, their photosynthesis and growth rely on nutrients such as phosphate. How phytoplankton regulate P nutrition is poorly understood.