Communications Biology
An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
Telomere maintenance and tumor cell differentiation have been separately investigated in neuroblastoma malignancy. Their mechanistic connection is unclear. We establish a tight and reciprocal causal relationship between the telomere and differentiation programs of high-risk neuroblastoma.
Cornering the interactome to kill cancer cells
Joshi et al reveal how manipulating cancer cell protein-protein interactions networks (i.e. interactomes) eliminates rebound pathways, turning traditionally less effective therapeutics highly efficacious.
GWAS for lung function with adjustment for exhaled nitric oxide levels as airway inflammation indicator
We performed a GWAS for lung function with adjustment for exhaled nitric oxide (FeNO) levels to account for type 2 airway inflammation. Our study identified the genetic locus most strongly associated with airway obstruction in the Japanese population and new genetic loci associated with FeNO.