An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the biological sciences, representing significant advances and bringing new biological insight to a specialized area of research.
Pancreas or islet transplantation have been performed with the goal of curing diabetes mellitus. Recently, gene therapy and regenerative medicine using iPS or ES cells have also been newly proposed. However, these therapies are not sufficient for more than 500 million patients in the world 1.
Finding the hidden needle: a workflow for 3D cryo-correlative light and electron microscopy volume imaging
Imagine capturing 3D images of whole tissue in an unperturbed hydrated state, transitioning from 3D cryo-light microscopy to 3D cryo-electron microscopy. Now this is possible with our 3D cryoCLEM workflow.