Many drugs are poorly soluble in water and require suitable formulation for oral administration. The use of polymer excipients in amorphous solid dispersions of drugs has emerged as a promising strategy. This requires the identification of suitable polymers for the drug of interest.
Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching
Understanding the conformational coupling mechanism between a protein and a conjugated fluorophore enables structure-based biosensor design