Communications Chemistry

An open access journal from Nature Portfolio publishing high-quality research, reviews and commentary in all areas of the chemical sciences.

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Photoreactive fragment pharmacophores explore potential binding sites and provide hits for highly challenging drug targets

Photoaffinity-tagged fragments are increasingly used for convenient hit detection and binding site mapping in early drug discovery. We tackled two important challenges by maximizing the pharmacophore diversity of the core fragments, and by enhancing the labelling efficiency of the photoaffinity tag.
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David Bajusz and 1 other
Sep 11, 2024