A recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of indolizine-2-carbaldehydes
We propose in this study an iminium ion/enamine tandem sequence that could efficiently overcome energy barriers encountered in Michael and aldol reactions during [3+2] annulations of acyl pyridines and α,β-unsaturated aldehyde for the construction of diverse indolizine-2-carbaldehydes.
Biophysical alterations of lipid membranes upon peroxidation are linked to cellular signalling and disease. Here, we show how lipid peroxidation breaks the correlation between the membrane’s elastic and viscous properties; and how it triggers lipid clustering in single-component membranes.
Alan Turing proposed one of the most influential theories of morphogenesis, in which a system of diffusive and reactive chemicals can produce stationary (and other types) spatial patterns. We explored the effect of periodic feeding of the reactive chemicals on pattern development and stabilty.
Our group started to study more advanced optimization techniques using machine learning to present a simpler, more practical, and rapid process for predicting the optimum reaction conditions that can be applied to several manufacturing environmentally sustainable processes.