SPARK at Stanford offers a unique model to advance and de-risk therapeutic research in academia
UBS-seq: An ultrafast bisulfite sequencing method more accurately detecting 5-methylcytosine in DNA and RNA
Current bisulfite sequencing (BS-seq) suffers from notable limitations such as long reaction time, severe DNA damage, overestimation of modification level etc. UBS-seq overcomes these limitations and detects 5-methylcytosine in DNA and RNA accurately starting from low input biological samples.
The human gut contains not only bacteria, but also viruses. Our new tool Phanta allows researchers to quantify these populations simultaneously, offering insights into their complex interactions.
We have designed a new method, Binding Affinities to Native Chromatin by sequencing (BANC-seq), to determine transcription factor concentrations needed to bind regulatory elements in the genome. We show that chromatin context and DNA accessibility are key regulators of transcription factor binding.