Functional studies of RNA pseudouridine (Ψ) modification have been limited by lacking quantitatively map individual Ψ sites transcriptome-wide. To address this challenge, Dai et al. developed BID-seq, a method for quantitative mapping of Ψ at single-nucleotide resolution.
While intellectual property played a role in building technology platforms, the real star incentive bringing vaccines and antivirals forward was public sector investment, most prominently procurement. Understanding this reality provides an opportunity for proactive planning before the next pandemic.
We all produce and discharge excretions into the sewer. Correspondingly, sewerage can tell a lot about its contributory population. In the case of the ongoing COVID-19 pandemic, wastewater-based epidemiology can serve as a tool for population wide pathogen surveillance without compliance issues.