Dissecting the natural history of IDH-mutant gliomas
Our work reveals that as IDH mutant gliomas progress, their cell states and key drivers change.
Nature Cancer
This journal aims to provide a unique forum through which the cancer community will learn about the latest, most significant cancer-related advances across the life, physical, applied and social sciences.
PD-1 expression in γδ T cells: What does this mean?
Here, we explore the immunological relevance of PD-1 expression in tissue resident Vδ1+ γδ T cells and discuss the subsequent implications for cancer immunotherapy.
How the vasculature controls adipose tissue wasting in cancer cachexia
Tissue wasting occurs frequently in patients with advanced cancer. Here, researchers show that the vasculature in adipose tissue responds to tumor-secreted factors by the release of soluble molecules (so called angiokines) acting in a paracrine manner to amplify wasting of white adipose tissue.
Niche heterogeneity influences the outcomes in myeloproliferative neoplasms
The reasons underlying the different pathogenesis and response to therapies in the myeloproliferative neoplasms have remained enigmatic. Grockowiak et al. provide some clues emerging from disease-specific alterations in the interaction of hematopoietic stem cells with their bone marrow niches (1).
