Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
MET-N375S: A therapeutically-actionable germline polymorphism in Asian cancer patients
We found that the most common polymorphism known to affect the MET gene (Asn375Ser [N375S]) increases the aggressiveness of squamous cell carcinoma of the lung, head and neck, and is unexpectedly amenable to HER2 blockers but resistant to c-Met inhibitors.