Second generation AR antagonists, abiraterone and enzalutamide, induce aberrant HGF/MET and Wnt pathways leading to increased XPO1 expression and ribosomal biosynthesis in double-null prostate cancer (DNPC). However, treatment with XPO1 and ribosomal inhibitors showed an improved antitumor response.
A connectivity signature for glioblastoma – towards a molecular and phenotypical understanding of the deadliest brain tumor in adults
A low-latitude loess profile from China revealed the dominant ~20,000-year cycle in rainfall change in the core zone of the East Asian summer monsoon, driven by variation in insolation controlled by precession, and precipitation and temperature variation may not follow the same orbital-scale cycles.
An overview of the paper: “Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients”. Blog post authors: Lisandra Aguilar-Bultet; Sarah Tschudin-Sutter.