Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
Gene expression tuning made easy
Have you ever wished to tune endogenous gene expression? Wait no longer.
In this “Behind the paper” blog post, I will present you our new toolkit, CasTuner, which is specifically designed to tune endogenous gene expression. I will summarize how CasTuner works, how to and why you should use it.
Introducing epiLiver: A High-throughput Test for Early Detection of Hepatocellular Carcinoma
HKG Epitherapeutics and icddr,b present epiLiver, a novel DNA methylation-based test poised to transform early detection of hepatocellular carcinoma (HCC). This innovative test offers a new hope in improving survival rates for those affected by this prevalent cancer.
Trajectories of freshwater microbial genomics and greenhouse gas saturation upon glacial retreat.
In this study, we did fieldwork in the remote high Arctic close to 80 oN at Svalbard as well as in the alpine, glaciated landscapes of Norway. The question we address here was how the aquatic microbial communities change along a glacial retreat gradient combined with analysis of greenhouse gases.
Large anomalies in future extreme precipitation sensitivity driven by atmospheric dynamics
We attributed extreme scaling into atmospheric thermodynamic and dynamic components and further decompose the thermodynamic effects into more details to reveal the physics of extreme precipitation under climate warming.
Mechanism for Fluctuating Pair Density Waves
Pair density waves (PDWs) and `fluctuating' PDWs (FPDWs) are modulated superconducting states that manifest in novel quantum materials. We provide a unified theoretical framework that explains the FPDW, PDW and ordinary (uniform) superconducting phases under a single paradigm.
A quantitative peek into the superresolution subcellular world
Incorporating a physical model differentiating in-focus and out-of-focus emissions eliminates background fluorescence without affecting genuine signals. With this added to the sparse deconvolution pipeline, we preserve weak signals and minimize artifacts while achieving a sub-70 nm resolution.
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche
Our study sought to identify key elements of the tumor microenvironment (TME) that drive distinct tumor states by defining the spatial organization of the TME. We find the proliferative neighborhood matures TREM2+ immunosuppressive myeloid cells into a self-propagating tumor-immune niche.
