Have you ever wished to tune endogenous gene expression? Wait no longer. In this “Behind the paper” blog post, I will present you our new toolkit, CasTuner, which is specifically designed to tune endogenous gene expression. I will summarize how CasTuner works, how to and why you should use it.
HKG Epitherapeutics and icddr,b present epiLiver, a novel DNA methylation-based test poised to transform early detection of hepatocellular carcinoma (HCC). This innovative test offers a new hope in improving survival rates for those affected by this prevalent cancer.
In this study, we did fieldwork in the remote high Arctic close to 80 oN at Svalbard as well as in the alpine, glaciated landscapes of Norway. The question we address here was how the aquatic microbial communities change along a glacial retreat gradient combined with analysis of greenhouse gases.
We attributed extreme scaling into atmospheric thermodynamic and dynamic components and further decompose the thermodynamic effects into more details to reveal the physics of extreme precipitation under climate warming.
Pair density waves (PDWs) and `fluctuating' PDWs (FPDWs) are modulated superconducting states that manifest in novel quantum materials. We provide a unified theoretical framework that explains the FPDW, PDW and ordinary (uniform) superconducting phases under a single paradigm.
Cultured meat platform developed through the structuring of edible microcarrier-derived microtissues with oleogel-based fat substitute
Incorporating a physical model differentiating in-focus and out-of-focus emissions eliminates background fluorescence without affecting genuine signals. With this added to the sparse deconvolution pipeline, we preserve weak signals and minimize artifacts while achieving a sub-70 nm resolution.
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche
Our study sought to identify key elements of the tumor microenvironment (TME) that drive distinct tumor states by defining the spatial organization of the TME. We find the proliferative neighborhood matures TREM2+ immunosuppressive myeloid cells into a self-propagating tumor-immune niche.