Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
SnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data
Multiplexed DNA fluorescence in situ hybridization (FISH) imaging technology has been developed to map the folding of chromatin fibers at tens of nanometers and several kilobases in resolution in single cells. We present SnapFISH to process the multiplexed DNA FISH data and identify chromatin loops.
Stem cell-like CD8 T cells are at the heart of the anti-tumor response induced by PD-L1/TGFβ dual blockade in immune excluded tumors
In depth analysis of the CD8 T cells infiltrating an immune excluded tumor model revealed the presence of stem cell-like CD8 T cells that expanded in situ upon anti-PD-L1/TGFβ combination therapy fueling an efficient and IFNγ dependent anti-tumor response.
