Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering
We employed CD16 as a biomarker to identify and select Vδ2 T cell PBMC donors. CD16 high Vδ2 T cells were then engineered with a Mesothelin-targeted chimeric antigen receptor and soluble IL-15 for the treatment of ovarian cancers
Double Boron–Oxygen-Fused Polycyclic Aromatic Hydrocarbons: Skeletal Editing and Applications as Organic Optoelectronic Materials
The development of chemically diverse boron-oxygen-fused polycyclic aromatic hydrocarbons has been limited by their synthetic complexity. Here, authors report a one-pot strategy for their facile synthesis and demonstrate their potential as ultralong afterglow and host materials for deep-blue OLEDs.
Unusually low oxygen and acidified water found in a high seas fishable area of the Pacific Arctic Ocean – A priority area of marine environmental and ecosystem monitoring for potential high seas fisheries –
Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy
A new laser-based scanning technology shows the capability to image fresh tissues with histological realism and with the speed and resolution needed for intra-operative analysis of resected tissues.