Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
DeepRTAlign: toward accurate retention time alignment for large cohort mass spectrometry data analysis
Retention time (RT) alignment is a crucial step in large cohort proteomics and metabolomics studies. Here, the authors introduce DeepRTAlign, a deep learning tool for RT alignment that shows high identification sensitivity and quantitative accuracy.
Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics
Bacterially secreted amyloid fibrils were shown for the first time to catalyze the degradation of β-lactam antibiotics. This observation points to possible antibiotic resistance mechanisms associated with bacterial biofilms.
“Effective interactions” shape the evolution of drug resistance (and much more)
In a new study, we examine how global epistasis—where gene-gene interactions follow a tractable pattern—is shaped by the environment, and defines how drug resistance evolves in malaria. This may allow us to better predict and control adaptive evolution at the molecular level.
