Nature Methods
This journal is a forum for the publication of novel methods and significant improvements to tried-and-tested basic research techniques in the life sciences.
Quantifying Cell-State Densities in Single-Cell Phenotypic Landscapes Using Mellon
What constitutes a tissue based on single-cell data and how can we represent it computationally? This question led us to develop Mellon, a tool to quantify cell-state densities and reveal dynamics of cell-differentiation processes. Here's a behind-the-scenes look at our journey.
TISSUE: Predicting missing spatial gene expression with confidence
Several computational methods have been developed to augment spatially resolved single-cell transcriptomics to measure more genes. We developed TISSUE to build on these methods by providing confidence in these computational measurements and additional tools for performing data analysis.
