Nature Protocols
This journal publishes secondary research articles and covers new techniques and technologies, as well as established methods, used in all fields of the biological, chemical and clinical sciences.
Raman spectroscopy for real-time and in situ monitoring of mechanochemical milling reactions
Raman spectroscopy is an essential technique of process analytical technologies used in the chemical and biopharmaceutical industry for uninterrupted monitoring of manufacturing processes. Now, it is also a powerful tool for monitoring solid-state milling reactions on vibratory ball mills.
Raman spectroscopy for cancer cytopathology
Early detection of cancer is key to better outcomes for patients, and cancer screening using minimally invasive samples such as blood, urine, saliva and exfoliated cells is receiving increasing attention.
Human fetal whole body post-mortem microfocus computed tomographic imaging
Pregnancy loss is a devastating event and whilst conventional autopsy techniques can provide parents with answers as to the cause of their loss, many decline due to its invasive nature. We describe micro-CT as an alternative to conventional autopsy and why this is more acceptable to parents.
Screening Host Defense Peptide Libraries for Antibiofilm and/or Immunomodulatory Activities
Systematic assays suitable for use with peptide arrays are described in this protocol to evaluate biological activities associated with host defense peptides (HDPs), such as biofilm inhibition and/or immunomodulatory properties.
Equip your microscope with a mechanical imaging module
An optical Brillouin microscope can quantify the mechanical properties of biological materials in 3D.