Nature
A weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions.
Pervasive lesion segregation shapes cancer genome evolution, a new paper from The Liver Cancer Evolution Consortium reveals fundamental insights into mutagenesis. The discovery shows how unrepaired DNA damage generates genetic diversity and provides unprecedented views of DNA repair processes.
Dysbiosis discovered in plants
Most of us are familiar with the term “Inflammatory Bowel Disease (IBD)”. However, you likely have not heard about “Inflammatory Phyllosphere Disease (IPD)”. This is because I have just made it up to draw your attention, and to describe a form of dysbiosis in plants that we have just reported.
Autophagy mediates evasion of bacterial missiles by mediating the release of decoy flares
Many disease-causing bacteria secrete pore-forming toxins that target the plasma membrane of host cells. We uncovered a counter defence response by the host involving the release of extracellular vesicles, defensosomes, downstream of innate immune activation of autophagy proteins.