npj Breast Cancer
This journal publishes original research articles, reviews, brief communications, matters arising, meeting reports and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas or the framing of new questions that need to be solved.
This study examined ribociclib pharmacokinetics and pharmacogenomics in 14 Black women with advanced breast cancer. The LEANORA study (NCT04657679) revealed that the ribociclib exposure and toxicity profile were similar between intermediate/normal and poor CYP3A5 metabolizers.
Targeting fatty acid synthase in preclinical models of triple-negative breast cancer brain metastases synergizes with chemotherapy and impairs invasion
Metastatic triple-negative breast cancer cells need to acquire the ability to produce new fatty acids to more effectively colonize the brain. Our study investigates how this metabolic vulnerability can be targeted to increase efficacy of chemotherapies and impair cancer cell invasion.