npj Parkinson's Disease
This journal publishes original basic science, translational and clinical research related to Parkinson's disease, including anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology and therapeutic development and treatments.
Parkinson's Disease: Can Metabolomics Predict and Explain Its Onset?
The uncertain pathogenesis of Parkinson's disease (PD) is suspected to predate symptom onset. Our study delves into the metabolic associations of PD before and after its onset to provide additional insights into its multifaceted aetiology.
The Role of Smartwatch Data in Monitoring Non-Motor Symptoms of Parkinson’s Disease
Accurate and continuous monitoring of symptoms can enable better care and timely intervention. Wearables could facilitate this but are underexplored for monitoring of non-motor symptoms.
A potential patient stratification biomarker for Parkinson's disease based on LRRK2-mediated cellular alterations in peripheral blood
A recent study substantiates a role for increased LRRK2 kinase activity in some idiopathic Parkinson's disease patients and suggests that blood-based patient stratification approaches hold promise in nominating patients who may benefit from LRRK2-related therapeutics.
Rescuing retromer in Parkinson's disease
Both Vp35 p.D620N and LRRK2 pathogenic variants cause late-onset, familial Parkinson's disease. In vivo, we show Vps35 p.D620N activates LRRK2 kinase activity, impairs the recycling and physiologic function of the dopamine transporter (DAT), and can be rescued by LRRK2 kinase inhibitors.
Wearable sensors provide early detection of progression in Parkinson’s Disease
For the first time, we have shown that it is possible to track disease progression of Parkinson's using machine learning to analyse data derived from sensor devices worn by patients.
