Oncogene
This journal aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research.
Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression
In this paper we identify Dock2 as an immune regulator in IBD-CRC, with potential therapeutic opportunity in this area of unmet clinical need.
AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis
AF1Q is an oncogene with roles in leukemia and solid tumor progression. Despite its expression in neural tissues, no role for AF1Q in tumors of neural origin has been reported. We found AF1Q is a universal marker of neuroblastoma that is essential for neuroblastoma cell survival and tumorigenicity.
TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC
This study identified the significant role of TRAIP in inhibiting BLCA progression, and revealed that TRAIP expression is significantly downregulated in BLCA and is strongly associated with poor prognosis.
TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD
Oncogene-TRIM69 suppressed the anoikis resistance and metastasis of gastric cancer through ubiquitin‒proteasome-mediated degradation of PRKCD
