Signal Transduction and Targeted Therapy

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

This study has recently been accepted in Signal Transduction and Targeted Therapy. The study reveals a new immune checkpoint of NK cells functional in the livers, a TM4SF5 and SLAMF7 linkage, and TM4SF5-specific isoxazole-based small molecules inhibitory against the linkage.

Lee, Jung Weon

Jan 20, 2025

Signal Transduction and Targeted Therapy

Behind the Paper

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

LncRNA HDRACA is involved in the high-density lipoprotein (HDL) regulation of angiogenesis. Normal HDL (nHDL) inhibits the expression of HDRACA to induce angiogenesis, and dysfunctional HDL (dHDL) is much less effective in inhibiting HDRACA expression and inducing angiogenesis.

Jingsong Ou

Aug 15, 2023

Signal Transduction and Targeted Therapy

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

Targeting IL-1α in metastatic colon cancer: a clinical feasibility study showing promising results in a phase 1 trial.

Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut

Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

DNA of neutrophil extracellular traps promote autoimmunity in chronic obstructive pulmonary disease

Leveraging different types of bodily fluids for cancer research

SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

EZH2 Inhibitors Advance β-like Cell Regeneration

Discovery of a Potent Glutaminyl-peptide Cyclotransferase-like Protein (QPCTL) inhibitor with In Vivo Antitumor Efficacy

Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression

Bridging the Gap: The Evolution of a Stem Cell Therapy for Meniscus Injuries

CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability

Vascular aging-targeted intervention based on NAD+ elevation as a novel measure to treat hypertension

Deciphering the effect of short-term fasting on the brain metabolism

NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response

Organoids meet single-cell and spatial omics

A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy

Signal Transduction and Targeted Therapy

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