Signal Transduction and Targeted Therapy
This is an international, peer-reviewed, open-access journal publishing articles related to signal transduction in physiological and pathological processes, alongside signal transduction-targeted therapeutics in the form of biological agents and small molecular drugs used to treat human diseases.
Behind the Paper: Potent antagonist for the MAS-related G protein-coupled receptor and its mouse ortholog with anti-inflammatory, anti- asthmatic, and anti-anaphylactic efficacy in human mast cells and mice
This is the story behind the paper by Al Hamwi et al., recently published in Signal. Transduct. Target. Ther. 2025, 10, 128. doi: 10.1038/s41392-025-02209-8.
Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage
This study has recently been accepted in Signal Transduction and Targeted Therapy. The study reveals a new immune checkpoint of NK cells functional in the livers, a TM4SF5 and SLAMF7 linkage, and TM4SF5-specific isoxazole-based small molecules inhibitory against the linkage.
SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK
This article describes how increased chondroitin sulfate may contribute to the pathogenesis of Covid-19 due to increased biosynthesis and reduced arylsulfatase B-mediated degradation.
High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA
LncRNA HDRACA is involved in the high-density lipoprotein (HDL) regulation of angiogenesis. Normal HDL (nHDL) inhibits the expression of HDRACA to induce angiogenesis, and dysfunctional HDL (dHDL) is much less effective in inhibiting HDRACA expression and inducing angiogenesis.
