Signal Transduction and Targeted Therapy
This is an international, peer-reviewed, open-access journal publishing articles related to signal transduction in physiological and pathological processes, alongside signal transduction-targeted therapeutics in the form of biological agents and small molecular drugs used to treat human diseases.
SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK
This article describes how increased chondroitin sulfate may contribute to the pathogenesis of Covid-19 due to increased biosynthesis and reduced arylsulfatase B-mediated degradation.
High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA
LncRNA HDRACA is involved in the high-density lipoprotein (HDL) regulation of angiogenesis. Normal HDL (nHDL) inhibits the expression of HDRACA to induce angiogenesis, and dysfunctional HDL (dHDL) is much less effective in inhibiting HDRACA expression and inducing angiogenesis.
The SARS-CoV-2 Spike protein: more than an entry key to heart damage
Our journey towards the discovery of the clever strategy adopted by SARS-CoV-2 to damage heart vascular cells far from the primary infection site: Spike protein shed from viral particles travels in the peripheral circulation and reaches the heart - like a messenger spreading the virus word.
