Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Microbiology
CARPID: Capture RNA-Protein interactions in living cells
We developed CARPID method to identify binding proteins of specific lncRNAs in the native cellular context, which jointly leverages enzymatically inactive CRISPR/dCasRx-based RNA targeting and proximity biotin-labeling.
Programming Bacterial Communication for Teamwork in a Test Tube
Building bacterial communities that work together, like a team of specialists, is a promising way to create advanced biological computers. In this study, we combine a phage-based messaging system with CRISPR gene regulation, allowing Escherichia coli bacteria to process information collectively.
The memory of salt: searching for ancient microbial life biosignatures on Earth and Mars
Salt: both friend and foe. On Earth and Mars, some brines may preserve traces of ancient microbial life, others may destroy them. Using dead halophile cell envelope extracts, we show that UV and salt composition together control biosignature preservation. To get there, we had to tame salt in the lab
