Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Lactate, a tumour-cell metabolite, promotes immune evasion via GPR81: A potential novel strategy to boost cancer immunotherapy?
Tumour cells generate lactate as a signaling molecule to aid in growth and metastasis. We have uncovered a novel function for this metabolite; it blunts the ability of the body’s immune system to recognize and kill tumour cells, thus making it possible for the cancer to evade immune attack.