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Engineering extracellular vesicles to target T cells

Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting domains and fusogenic glycoproteins.
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Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Nature
Nature Nature

Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells - Nature Biomedical Engineering

Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting domains and fusogenic glycoproteins.

The cover illustrates that extracellular vesicles can be engineered with multiple functionalities for the targeted delivery of biologics to T cells.

See Stranford et al.

Image: Justin Muir. Cover design: Alex Wing.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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