Phenotyping intratumoural heterogeneity
A method that identifies patterns of tumour heterogeneity in intact biopsy samples using 3D light-sheet microscopy stratifies patients by tumour stage.
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Bioengineering & Biotechnology
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Nature Biomedical Engineering
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The cover illustrates patterns of vascular heterogeneity in cleared solid tumours identified through light-sheet microscopy.
https://dx.doi.org/10.1038/s41551-017-0139-0
Image from Nobuyuki Tanaka and Per Uhlén.