Metabolic Approaches to Chronic Liver Disease; Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies
Published in Chemistry, General & Internal Medicine, and Pharmacy & Pharmacology
Metabolic Approaches to Chronic Liver Disease
Important Deadlines
Early Registration Deadline: December 30, 2026
Scholarship Deadline: November 4, 2026
Short Talk Abstract Deadline: November 4, 2026
Poster Abstract Deadline: February 9, 2027
Meeting Summary
Title: Metabolic Approaches to Chronic Liver Disease
Date: March 1 - 4, 2027
Location: Keystone Resort, Keystone, Colorado, USA
Scientific Organizers: Jay D. Horton, Bei B. Zhang, and Samuel Klein
Keynote Speaker(s): Helen H. Hobbs, University of Texas Southwestern Medical Center
Chronic liver disease affects more than 1.5 billion people and most commonly results from chronic infection with hepatitis B virus (HBV), hepatitis C virus (HCV), or steatotic liver diseases. Effective treatments exist for viral infections, but effective approaches to alter the course of MASLD are still understudied. The most common steatotic liver disease is Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has become a major public health problem because of its high world-wide prevalence of ~30%, association with serious cardiometabolic abnormalities, including diabetes, the metabolic syndrome, and coronary heart disease, and potential progression to severe liver disease, including advanced fibrosis/cirrhosis and hepatocellular carcinoma. The goals of this Keystone Conference are to provide the latest data that: 1) provide new insights into the molecular and physiological mechanisms that cause hepatic steatosis and its progression to advanced fibrosis; 2) identify the key metabolic targets for effective therapeutic intervention; 2) define and clarify the clinical implications of the underappreciated association between sarcopenia and MASLD and its therapeutic options; 3) critically evaluate the role of weight loss and exercise in treating people with MASLD and the most effective intervention strategies to prevent disease progression and improve co-morbidities; and 4) provide the rationale and results of the most promising early stage pharmacological interventions for MASLD. The expert speakers represent basic and translational researchers, and scientists from industry whose collective expertise will provide a comprehensive overview of how and why metabolic dysfunction causes MASLD and what interventions provide the best therapeutic opportunities for this increasingly common disease.
*This meeting will be held jointly with Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies
Join Options
Attend in person, via livestream, or catch sessions on demand after the conclusion of the conference.
*Keystone Symposia Scholarships & Awards*
Keystone Symposia offers discounted registration to students in undergraduate, M.S., Ph.D., or M.D. programs, providing access to the latest scientific advances, technologies, and approaches to further research and careers.
In addition, several financial aid opportunities are also available to support attendance at its scientific meetings:
- Student and Postdoctoral Scholarships provide up to $1,200 to help defray travel, lodging, registration, and related costs when presenting a poster at an in-person conference. Awards are competitive, based on the abstract’s scientific quality and relevance, and you must apply by the individual scholarship deadline for the desired meeting (abstract + mentor letter required).
- Early-Career Travel Awards (ECITAs) support early-career investigators with funding to attend meetings; these also require application by the posted deadline for each conference.
- Global Health Travel Awards (GHTAs) provide financial aid for scientists, clinicians, fellows, and students from low- and middle-income countries (LMICs) to participate in select Keystone Symposia meetings, especially those focused on global health topics. These awards may cover registration, lodging, airfare, and ground transportation, and applications are submitted through the Financial Aid Portal by the listed meeting deadlines. Learn which meetings have in-person GHTAs available: https://www.keystonesymposia.org/financial-aid/global-health-awards/ghta-listing
For details on eligibility, deadlines, and how to apply for financial aid, visit: https://www.keystonesymposia.org/financial-aid.
Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies
Important Deadlines
Early Registration Deadline: December 30, 2026
Scholarship Deadline: November 4, 2026
Short Talk Abstract Deadline: November 4, 2026
Poster Abstract Deadline: February 9, 2027
Meeting Summary
Title: Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies
Date: March 1 - 4, 2027
Location: Keystone Resort, Keystone, Colorado, USA
Scientific Organizers: Rafael Kramann, Rebekka Schneider, and Neil C. Henderson
Keynote Speaker(s): Carine Boustany, Boehringer Ingelheim
The Fibrosis Keystone conference has been highly successful for many years, however while organs like skin, liver, and lung have been covered extensively in previous meetings, other organs have received much less attention. From our conversations with peers at recent Keystone fibrosis meetings, we believe that covering a broader range of types of organ fibrosis, and hence stimulating rich, inter-organ scientific discussions, would be of great interest and benefit to the fibrosis community. To this end, in addition to the ‘core’ fibroses listed above, we propose to cover fibrosis in greater depth in other organs, including bone marrow, kidney, intestine, and fibrosis in the context of cancer. The clinical unmet need in fibrosis is very high. Although the only approved antifibrotic therapies are currently for lung fibrosis, many new therapies for multiple types of organ fibrosis are under development. This combination of factors has resulted in fibrosis becoming one of the hottest topics in biotech and the pharmaceutical industry, with major interest both from Venture Capital and ‘Big Pharma’. Therefore, we think that a Keystone Fibrosis conference focusing on the pathogenic mechanisms driving fibrosis across a broad range of organs, coupled with sessions focused on the burgeoning area of precision therapeutics in the context of fibrosis, will be of great interest to the community. The key concepts included will be:
Conserved and distinct mechanisms of fibrosis across multiple organs, such as kidney, bone marrow, heart, intestine, liver, lung, skin, and fibrosis in the context of cancer.
Discussions of the modalities driving drug development in fibrosis – e.g., cutting-edge antibody approaches, cell and gene therapy, small molecules, etc.
Sessions with Academic and Industry leaders discussing the state-of-the-art in antifibrotic development.
Sessions on the requirement for multimodal / combination therapies to tackle fibrosis.
Future directions / remaining open questions in fibrosis research and translation
*This meeting will be held jointly with Metabolic Approaches to Chronic Liver Disease
Join Options
Attend in person, via livestream, or catch sessions on demand after the conclusion of the conference.
*Keystone Symposia Scholarships & Awards*
Keystone Symposia offers discounted registration to students in undergraduate, M.S., Ph.D., or M.D. programs, providing access to the latest scientific advances, technologies, and approaches to further research and careers.
In addition, several financial aid opportunities are also available to support attendance at its scientific meetings:
- Student and Postdoctoral Scholarships provide up to $1,200 to help defray travel, lodging, registration, and related costs when presenting a poster at an in-person conference. Awards are competitive, based on the abstract’s scientific quality and relevance, and you must apply by the individual scholarship deadline for the desired meeting (abstract + mentor letter required).
- Early-Career Travel Awards (ECITAs) support early-career investigators with funding to attend meetings; these also require application by the posted deadline for each conference.
- Global Health Travel Awards (GHTAs) provide financial aid for scientists, clinicians, fellows, and students from low- and middle-income countries (LMICs) to participate in select Keystone Symposia meetings, especially those focused on global health topics. These awards may cover registration, lodging, airfare, and ground transportation, and applications are submitted through the Financial Aid Portal by the listed meeting deadlines. Learn which meetings have in-person GHTAs available: https://www.keystonesymposia.org/financial-aid/global-health-awards/ghta-listing
For details on eligibility, deadlines, and how to apply for financial aid, visit: https://www.keystonesymposia.org/financial-aid.
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