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Tracking cell division with mass cytometry

Published in Bioengineering & Biotechnology

Go to the profile of Irene Jarchum
Irene Jarchum
Senior Editor, Nature Biotechnology
Tracking cell division with mass cytometry
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Nature
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Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells - Nature Biotechnology

Measuring proliferation history in single-cell mass cytometry enables control of T cell fate.

A major factor affecting the function and differentiation state of cells is their proliferation. Flow cytometry enables tracking the division of cells, but the cellular markers that can be measured is limited. In this paper published in Nature Biotechnology, Good et al. show that the CFSE dye dilution assay can be adapted for mass cytometry. With this, they use mass cytometry to track 23 markers and proliferation, examining the phenotype of T cells as they expand. They use this knowledge to build a map of these cell states, and based on this identify a signaling pathway that can be manipulated to differentiate cells towards a T stem cell memory-like phenotype.


Image credit: Otavio B. Good 


Go to the profile of Irene Jarchum
Irene Jarchum
Senior Editor, Nature Biotechnology

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