In this manuscript we provide evidence that the complementation of the baseline neurological medication of PKAN patients with pantothenate, pantethine (aiming to increase PANK2 and mtACP levels) and omega 3 and vitamin E (targeting oxidative stress and lipid peroxidation) could help in improving or delaying the progression of motor dysfunction. Novel targeted treatments are extremely needed to retard or stop disease progression and to optimize the quality of life in PKAN.
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In this manuscript we provide evidence that the complementation of the baseline neurological medication of PKAN patients with pantothenate, pantethine (aiming to increase PANK2 and mtACP levels) and omega 3 and vitamin E (targeting oxidative stress and lipid peroxidation) could help in improving or delaying the progression of motor dysfunction. Novel targeted treatments are extremely needed to retard or stop disease progression and to optimize the quality of life in PKAN.