Upon viscosity increase, from water-like to honey-like viscous drag will immediately redistribute the membrane originally stored in the ruffles, resulting in a 2-fold increase of spread area, formation of more focal adhesions, generating greater traction forces, and twice faster cell migration. See more details at this link.
Gallery | A human breast cancer cell immediately shifts its shape at high viscosity
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Membrane ruffling is a mechanosensor of extracellular fluid viscosity - Nature Physics
Living cells change their behaviour in response to the viscosity of the medium surrounding them. An in vitro study shows that cells spread wider and move faster in a highly viscous medium, provided they have an actively ruffling lamellipodium.
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