Nature
A weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions.
Targeting rewired metabolic pathways in pancreatic cancer
Pancreatic cancer cells rewire their metabolism to adapt to their nutritional environment. In this study, we show that targeting a new drug target, PIKfyve, disrupts lipid metabolism and sensitizes pancreatic cancer cells to KRAS-MAPK inhibitors.
Discovering Europe's Last Hunter-Gatherers
A chance discovery led to evidence of a vanished people - and the epic sea voyages they were never supposed to have undertaken.
Insights into composition of Earth's earliest crust and the onset of plate tectonics
Calculations of the composition of the Earth’s Hadean Protocrust show that it may
have been very similar in composition to todays continental crust. This bring into
question the utility of geochemical signatures to determine when plate tectonic began.
