Nature Communications
An open access, multidisciplinary journal dedicated to publishing high-quality research in all areas of the biological, health, physical, chemical and Earth sciences.
Safeguarding Blue Skies: Advanced Metal-Organic Frameworks for Pollution Remediation
Benzene and SO2 coexist as hazardous air pollutants. Here we synthesized a robust pyrazolate MOF sorbent with accessible Ni2+ sites that can simultaneously capture trace amounts of benzene and SO2 under humid conditions.
TPE-Embedded Butterfly Bis-Crown Ether with Controllable Conformation and Supramolecular Chiroptical Property
A series of bis-crown ethers with AIE-active TPE core are synthesized via intramolecular McMurry coupling. The incorporation of flexible side chains into the rigid TPE core results in specific strain on the molecules, generating two conformers with specific semi-rigid symmetric/asymmetric structures
Evolutionary Studies Drive the Elucidation of Plant Natural Product Biosynthetic Pathways
Plant natural products are a major source of pharmaceuticals, with over one-third of FDA-approved drugs derived from natural products and their derivatives.
A unified model for interpretable latent embedding of multi-sample, multi-condition single-cell data
The advent of single-cell technologies has allowed us not only to generate comprehensive atlases of cell types in their 'normal' states, but also to understand how these cells change under various conditions. Here, we introduce GEDI, a framework to enable the analysis of these datasets.
Highly potent and broadly neutralizing anti-CD4 trimeric nanobodies inhibit HIV-1 infection by inducing CD4 conformational alteration
In one of our studies published in Nature Communications, we discover Nb457, an alpaca-derived nanobody with broad-spectrum anti-HIV-1 activity. Nb457 induces conformational changes in CD4, blocking viral entry. Its trimeric form achieves complete HIV-1 inhibition, promising treatments.
