Supramolecular engagers of tumour cells and T cells with an ‘off’ switch

The off-tumour toxicity of a supramolecular bispecific T-cell engager can be halted by disengaging T cells from the tumour cells via the disassembly of the supramolecular aggregate through the infusion of the small-molecule drug amantadine.
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The cover illustrates the small-molecule-mediated control of the antitumour activity of a supramolecular bispecific T-cell engager through its disassembly.

See Gong et al.

Image: Ningqiang Gong. Cover design: Alex Wing.

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