Collection Overview 

Scientific Reports has launched a Guest-Edited Collection on Nitric oxide signalling in cardiovascular health and disease. 

Acting as a second messenger, endogenous nitric oxide (NO) is derived from both enzymatic (nitric oxide synthase; NOS) and non-enzymatic sources. While it has been well-documented that endothelial derived NO is involved in promoting cardiovascular health, dysregulated NO synthesis and bioactivity appears to be involved in driving vascular inflammation and has been reported to contribute to cardiovascular disease. Therefore, further research is necessary to improve our understanding of the role of NOS/NO signalling in the cardiovascular system, particularly in the context of cardiovascular disease.

Research in this field may include, but is not limited to, the role of genetic predisposition in NOS/NO signalling, regulation of NO synthesis, modulation of NOS/NO signalling and its downstream targets, and the development and use of NO signalling therapeutics for cardiovascular disease. 

This will be a Collection of original research papers  and will be open for submissions from all authors – on the condition that the manuscripts fall within the scope of the Collection and of Scientific Reports more generally. We are welcoming submissions until 30th January 2026.

Why is this Collection important?

"Nitric oxide (NO) sits at the core of vascular health through its regulatory role in endothelial function, vascular tone, and thrombosis. This Collection brings together the latest research on NO signalling pathways, genetic influences, regulatory mechanisms, and emerging therapeutics. Together, the studies submitted for the Collection will deepen our understanding of how NO signalling shapes cardiovascular function and how its dysregulation can be targeted to improve clinical outcomes. "

- Dr. Shelby Bollen, In House Editor

Why submit to a collection?  

Collections like this one help promote high-quality science. They are led by Guest Editors, who are experts in their fields, and In-House Editors and are supported by a dedicated team of Commissioning Editors and Managing Editors at Springer Nature. Collection manuscripts typically see higher citations, downloads, and Altmetric scores and provide a one-stop-shop on a cutting-edge topic of interest.  

Who is involved?

Guest Editors:

• Huige Li, Johannes Gutenberg University, Mainz, Germany
• Roman N. Rodionov, Dresden Institute of Technology, Dresden, Germany
• John M. Seubert, University of Alberta, Edmonton, Canada

Internal Team:

• In-House Editor: Shelby Bollen, Scientific Reports, UK
• Commissioning Editor: Sophie Gray, Fully OA Brands, Springer Nature, UK
• Managing Editor: Libby Symons, Fully OA Brands, Springer Nature, UK

How can I submit my paper?

Visit the Collection page for more information on the Collection, and how to submit your article.