Can we treat cancer with the microbiota?
We focused on microbiota members that are underrepresented in the early stages of tumorigenesis and found a mouse strain (Faecalibaculum rodentium PB1) and its human counterpart (Holdemanella biformis) to be underepresented in mouse models or human intestinal advanced adenoma patients. Both strains release short chain fatty acids and control tumor growth in vitro and in vivo.
This is just the beginning of identification of microbiota members that might eventually be used to treat cancer.
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Nature Microbiology
An online-only monthly journal interested in all aspects of microorganisms, be it their evolution, physiology and cell biology; their interactions with each other, with a host or with an environment; or their societal significance.
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