Behind the Paper

Can we treat cancer with the microbiota?

We heard a lot of correlations between microbiota modifications and cancer development, particularly colorectal cancer. Many different species have been associated with the tumor state and some have also demonstrated to be causative as Fusobacterium nucleatum.

Published in Microbiology

Go to the profile of Maria Rescigno
Maria Rescigno
Professor, Humanitas University
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Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth

Nature Microbiology - The murine gut commensal Faecalibaculum rodentium and its human homologue, Holdemanella biformis, are under-represented in tumour development and can reduce tumour progression…

We focused on microbiota members that are underrepresented in the early stages of tumorigenesis and found a mouse strain (Faecalibaculum rodentium PB1) and its human counterpart (Holdemanella biformis) to be underepresented in mouse models or human intestinal advanced adenoma patients. Both strains release short chain fatty acids and control tumor growth in vitro and in vivo. 
This is just the beginning of identification of microbiota members that might eventually be used to treat cancer. 

Go to the profile of Maria Rescigno
Maria Rescigno
Professor, Humanitas University

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Microbiology
Life Sciences > Biological Sciences > Microbiology

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