Formulation Matters: Influence of Water Content and Packaging on Stability and Safety of Sevoflurane
Published in Biomedical Research
While regulatory designations of “therapeutic equivalence” assure similar clinical efficacy, they do not account for formulation-specific chemical behavior. Sevoflurane stability, and patient and equipment safety are significantly influenced by water content and pack aging material. Awareness of these factors is essential, particularly in high-volume operating environments, teaching hospitals, and resource-limited settings where vaporizers are often shared. A proactive, evidence-based approach to formulation selection can reduce the risk of HF formation, equipment corrosion, and adverse events. Anesthesiologists must recognize that formulation matters, not only for efficacy but for the safety of patients, staff, and the devices they rely on.
Dr. Somchai Amornyotin is a Professor at the Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University. From 2005 until 2009 he was the chief of the Anesthesiology Division of Siriraj GI Endoscopy Center, Faculty of Medicine Siriraj Hospital, Mahidol University. His first scientific paper was published in Thailand in 1999. He has practiced anesthesia for gastrointestinal endoscopy since 2002. He was on the committee of Siriraj Gastrointestinal Endoscopy Center, Faculty of Medicine Siriraj Hospital in 2005. More than 80 of his articles have been published in Thai and international medical journals. Dr. Amornyotin is a member and committee of the Royal College of Anesthesiologists of Thailand, the Gastroenterological Association of Thailand, and many scientific societies. He is the reviewer and editor of many international journals.
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