Nalbuphine as an Intrathecal Adjuvant: a Minireview
Published in Biomedical Research
The use of nalbuphine, a mixed opioid agonist-antagonist, as an intrathecal adjuvant has garnered significant attention in recent years. Its role in enhancing analgesic efficacy, prolonging the duration of spinal anesthesia, and reducing opioid-related side effects presents a promising alternative in clinical anesthesia practice. This review article explores the pharmacological properties of nalbuphine, its mechanisms of action, and its clinical applications as an intrathecal adjuvant. Additionally, we evaluate the outcomes, safety profile, and limitations based on existing literature to provide a comprehensive understanding of its utility.
Dr. Somchai Amornyotin is a Professor at the Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University. From 2005 until 2009 he was the chief of the Anesthesiology Division of Siriraj GI Endoscopy Center, Faculty of Medicine Siriraj Hospital, Mahidol University. His first scientific paper was published in Thailand in 1999. He has practiced anesthesia for gastrointestinal endoscopy since 2002. He was on the committee of Siriraj Gastrointestinal Endoscopy Center, Faculty of Medicine Siriraj Hospital in 2005. More than 80 of his articles have been published in Thai and international medical journals. Dr. Amornyotin is a member and committee of the Royal College of Anesthesiologists of Thailand, the Gastroenterological Association of Thailand, and many scientific societies. He is the reviewer and editor of many international journals.
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