Nalbuphine: Pharmacology Revisited
Published in Biomedical Research
Nalbuphine is a synthetic opioid analgesic with a unique profile as a mixed agonist-
antagonist. It acts as an antagonist at the mu-opioid receptor and an agonist at the
kappa-opioid receptor, providing effective analgesia for moderate to severe pain while
minimizing common opioid-related side effects such as respiratory depression, nausea, and
pruritus. Notably, nalbuphine has a lower potential for dependence and abuse compared
to traditional mu-opioid agonists. Its pharmacological properties make it a valuable option
in various clinical settings, including labor analgesia and the management of opioid-induced
pruritus.
Dr. Somchai Amornyotin is a Professor at the Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University. From 2005 until 2009 he was the chief of the Anesthesiology Division of Siriraj GI Endoscopy Center, Faculty of Medicine Siriraj Hospital, Mahidol University. His first scientific paper was published in Thailand in 1999. He has practiced anesthesia for gastrointestinal endoscopy since 2002. He was on the committee of Siriraj Gastrointestinal Endoscopy Center, Faculty of Medicine Siriraj Hospital in 2005. More than 80 of his articles have been published in Thai and international medical journals. Dr. Amornyotin is a member and committee of the Royal College of Anesthesiologists of Thailand, the Gastroenterological Association of Thailand, and many scientific societies. He is the reviewer and editor of many international journals.
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