New study: Vacuolar-type H⁺-ATPase-mediated extra-organellar buffering resolves mitochondrial dysfunction

Mitochondrial stress can reduce cellular performance and compromise survival. In our new work, we show that Vacuolar-type H⁺-ATPase (V-ATPase) supports an extra-organellar buffering response that helps restore mitochondrial function and improves cell fitness under mitochondrial stress.
Go to the profile of Christopher B. Jackson
Christopher B. Jackson
PI, University of Helsinki, Faculty of Medicine
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  • V-ATPase-dependent buffering outside organelles contributes to recovery from mitochondrial dysfunction and promotes better cellular fitness during stress.

📌 Paper link: https://www.nature.com/articles/s41467-025-66656-1

#Mitochondria #VATPase #CellFitness #StressResponses #CellBiology

Go to the profile of Christopher B. Jackson
Christopher B. Jackson (He/Him)
PI, University of Helsinki, Faculty of Medicine

The Jackson Lab at the University of Helsinki studies cellular homeostasis and mitochondrial quality control using functional genomics approaches.

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