About Pablo Zambrano
I am a researcher in membrane biophysics and protocell models with international experience gained at the Max Planck Institute of Biochemistry, the Technical University of Munich, and the University of Exeter. My work focuses on lipid membrane dynamics, selective permeability, and physicochemical processes relevant to early cellular evolution.
My research combines experimental membrane biophysics, microfluidics, and advanced imaging to investigate how simple lipid systems respond to chemical and thermal cues.
I am always open to collaborative research opportunities across membrane science, prebiotic chemistry, and synthetic biology.
Publications (*corresponding author)
16. Christine M. E. Kriebisch, Olga Bantysh, Lorena Baranda, Andrea Belluati, Eva Bertosin, Kun Dai, Maria de Roy, Hailin Fu, Nicola Galvanetto, Julianne M. Gibbs, Samuel Santhosh Gomez, Gaetano Granatelli, Alessandra Griffo, Maria Guix, Cenk Onur Gurdap, Johannes Harth-Kitzerow, Ivar S. Haugerud, Gregor Häfner, Pranay Jaiswal, Sadaf Javed, Ashkan Karimi, Shuzo Kato, Brigitte A. K. Kriebisch, Sudarshana Laha, Pao-Wan Lee, Wojciech P. Lipinski, Thomas Matreux, Thomas Michaels, Erik Poppleton, Alexander Ruf, Annemiek D. Slootbeek, Iris B. A. Smokers, Héctor Soria-Carrera, Alessandro Sorrenti, Michele Stasi, Alisdair Stevenson, Advait Thatte, Mai Tran, Merlijn H. I. van Haren, Hidde D. Vuijk, Shelley F. J. Wickham, Pablo Zambrano, Katarzyna P. Adamala, Karen Alim, Ebbe Sloth Andersen, Claudia Bonfio, Dieter Braun, Erwin Frey, Ulrich Gerland, Wilhelm T. S. Huck, Frank Jülicher, Nadanai Laohakunakorn, L. Mahadevan, Sijbren Otto, James Saenz, Petra Schwille, Kerstin Göpfrich, Christoph A. Weber, Job Boekhoven.
"A roadmap towards the synthesis of Life",
Chem, 11, 3, 102399 (2025). [Link]
15. Zambrano, P., Chen, X., Kriebisch, C., Kriebisch, B., Zozulia, O., *Boekhoven, J.
"Chemically Driven Division of Protocells by Membrane Budding",
Journal of American Chemical Society, 146, 49, 33359–33367 (2024). [Link]
14. *Zambrano, P.
"Membrane Interactions in Alzheimer`s Disease Treatment Strategies with Multitarget Molecules"
Bioorganic Chemistry, 147, 107407 (2024). [Link]
13. *Zambrano, P., Manrique-Moreno, M., Petit, K., Colina, J.C., Jemiola-Rzeminska, M., Suwalsky, M., *Strzalka, K.
"Differential Scanning Calorimetry in Drug - Membrane Interactions"
Biochemical and Biophysical Research Communications, 709, 149806, (2024). [Link]
12. *Zambrano, P.
"Exploring Multitarget Strategies for Membrane Protection in Alzheimer’s Disease"
ACS Chemical Neuroscience, 14, 22, 3972–3974 (2023). [Link]
11. *Zambrano, P., Suwalsky M, Jemiola-Rzeminska M, Gallardo-Nelson MJ, Strzalka K, Muñoz-Torrero D.
"A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer’s disease related Aβ(1-42) peptide"
Biophysical Chemistry, (300)107061, (2023). [Link]
10. *Zambrano, P.
"On the interaction of a donepezil-huprine hybrid with synthetic membrane models".
Neural Regeneration Research, 18(2):333-334 (2023). [Link]
9. *Zambrano, P., Suwalsky M, Jemiola-Rzeminska M, Gallardo-Nelson MJ, Strzalka K, Muñoz-Torrero D.
"Protective Role of a Donepezil-Huprine Hybrid against the β-Amyloid (1-42) Effect on Human Erythrocytes".
International Journal of Molecular Sciences, 22(17):9563 (2021). [Link]
8. *Zambrano, P., Suwalsky, M., Jemiola-Rzeminska, M., Strzalka, K., Aguilar, L.F.
"An in vitro study on the interaction of the anti-Alzheimer drug rivastigmine with human erythrocytes".
Chemico-Biological Interactions, 319 (2020). [Link]
7. Zambrano, P., Suwalsky, M., Jemiola-Rzeminska, M., Strzalka, K., Gallardo, M.J., Sepúlveda, B., Aguilar, L.F.
"The acetylcholinesterase (AChE) inhibitor and anti-Alzheimer drug donepezil interacts with human erythrocytes"
Biochimica et Biophysica Acta (BBA) – Biomembranes, 1861(6), 1078- 1085 (2019). [Link]
6. Zambrano, P., Suwalsky, M., Jemiola-Rzeminska, M., Strzalka, K.
"α1- and β-adrenergic agonist labetalol induces morphological changes in human erythrocytes."
Biochemical and Biophysical Research Communications, 503(1), 209-214 (2018). [Link]
5. *Zambrano, P., Suwalsky, M., Jemiola-Rzeminska, M., Strzalka, K.
"Studies on the interaction of NMDA receptor antagonist memantine with cell membranes: a mini-review"
Chemico-Biological Interactions, 283, 47-50 (2018). [Link]
4. Zambrano, P., Suwalsky, M., Villena, F., Jemiola-Rzeminska, M., Strzalka, K.
"In vitro effects of the anti-Alzheimer drug memantine on the human erythrocyte membrane and molecular models"
Biochemical and Biophysical Research Communications, 483(1), 528-533 (2017). [Link]
3. Suwalsky, M., Zambrano, P., Gallardo, M.J., Villena, F., Jemiola-Rzeminska, M., Strzalka, K.
"Effects of Thimerosal on Lipid Bilayers and Human Erythrocytes: An In Vitro Study"
Journal of Membrane Biology, 249(6), 823-831 (2016). [Link]
2. Suwalsky, M., Zambrano, P., Villena, F., Manrique-Moreno, M., Gallardo, M.J., Jemiola- Rzeminska, M., Strzalka, K., Edwards, A.M., Mennickent, S. Dukes, N.
"Morphological effects induced in vitro by propranolol on human erythrocytes"
Journal of Membrane Biology, 248(4), 683- 93 (2015). [Link]
1. Suwalsky, M., Zambrano, P., Mennickent, S., Villena, F., Sotomayor, C.P., Aguilar, L.F., Bolognin, S.
"Effects of phenylpropanolamine (PPA) on in vitro human erythrocyte membranes and molecular models"
Biochemical and Biophysical Research Communications, 406(3), 320- 325 (2011). [Link]
Miscellaneous scientific articles:
1. *Zambrano, P.
"Lindau: an inspirational meeting for young scientists" (in Spanish)Investigación y Ciencia, ISSN 0210-136X, No. 504, 2018, pp. 56-58 (Spanish Version of Scientific American Magazine).