About Stephen D Ginsberg
The main goal of the Ginsberg laboratory is to understand the molecular and cellular substrates that regulate selective vulnerability of neurons to degeneration.
A multidisciplinary approach of state-of-the-art functional genomics (including single population RNA-sequencing) and proteomics approaches combined with immunohistochemical and cell biological techniques is utilized as part of the experimental design. Particular emphasis is placed upon analyzing the fingerprint of single neurons as a means of understanding the complex cascade of cellular events that occurs under pathologic conditions such as aging, Alzheimer’s disease (AD), Down syndrome (DS), and mild cognitive impairment (MCI) as well as animal and cellular models of neurodegenerative disorders.